The numbers lean Buffalo Bills Buffalo Bills edge 5–0 on season record, scoring margin, recent form and recent meetings. 7 meetings in NFL on record. A read of the stats, not a tip.
Buffalo Bills lead the head to head 5–2 from 7 meetings since 2001. 2026: Buffalo Bills 6–1, Carolina Panthers 3–4. Buffalo Bills have the better margin, +7.4 a game to -2.1. Buffalo Bills have won the last 2 against Carolina Panthers. Last five: Buffalo Bills 4 wins, Carolina Panthers 2. Buffalo Bills are on a 3-game winning run. Carolina Panthers average more pass attempts per game: 39.1 to 29.3. At home: Buffalo Bills win 60%, Carolina Panthers 50% (every game we hold). Buffalo Bills’ biggest win in the rivalry: 40–9 in 2025, by 31. Carolina Panthers’ biggest win in the rivalry: 9–3 in 2017, by 6. Head to head 5 7 games 2
27 Oct 2025 · Bank of America Stadium, Charlotte 40 9 20 Dec 2021 · Highmark Stadium (Old), Orchard Park 31 14 18 Sept 2017 · Bank of America Stadium, Charlotte 3 9 16 Sept 2013 · Highmark Stadium (Old), Orchard Park 24 23 26 Oct 2009 · Bank of America Stadium, Charlotte 20 9 28 Nov 2005 · Highmark Stadium (Old), Orchard Park 9 13 10 Dec 2001 · Ralph Wilson Stadium 25 24 2026 season Per game, this season.
33.3 233 total Scored per gameper game 25.4 178 total
25.9 181 total Conceded per gameper game · lower is better 27.6 193 total
29.3 205 total Pass attemptsper game 39.1 274 total
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