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San Francisco 49ers v Arizona Cardinals: head to head | Lineball
San Francisco 49ers edge 5–0 on season record, scoring margin, recent form and recent meetings. 51 meetings in NFL on record. A read of the stats, not a tip.
San Francisco 49ers lead the head to head 29–22 from 51 meetings since 1999.
2026: San Francisco 49ers 6–1, Arizona Cardinals 3–5. San Francisco 49ers have the better margin, +8.3 a game to -7.9.
San Francisco 49ers have won the last 3 against Arizona Cardinals.
Last five: San Francisco 49ers 4 wins, Arizona Cardinals 2.
Arizona Cardinals average more pass attempts per game: 41.1 to 30.1.
At home: San Francisco 49ers win 57%, Arizona Cardinals 49% (every game we hold).
San Francisco 49ers’ biggest win in the rivalry: 50–14 in 2003, by 36.
Arizona Cardinals’ biggest win in the rivalry: 47–7 in 2015, by 40.
Built only from games in our stats database. A read of the numbers, not a tip.
Head to head
2951 games since 199922
28 Sept 2026 · Levi's Stadium, Santa ClaraSan Francisco 49ers 36Arizona Cardinals 30
17 Nov 2025 · State Farm Stadium, GlendaleSan Francisco 49ers 41Arizona Cardinals 22
22 Sept 2025 · Levi's Stadium, Santa ClaraSan Francisco 49ers 16Arizona Cardinals 15
6 Jan 2025 · State Farm Stadium, GlendaleSan Francisco 49ers 24Arizona Cardinals 47
7 Oct 2024 · Levi's Stadium, Santa ClaraSan Francisco 49ers 23Arizona Cardinals 24
18 Dec 2023 · State Farm Stadium, GlendaleSan Francisco 49ers 45Arizona Cardinals 29
2 Oct 2023 · Levi's Stadium, Santa ClaraSan Francisco 49ers 35Arizona Cardinals 16
9 Jan 2023 · Levi's Stadium, Santa ClaraSan Francisco 49ers 38Arizona Cardinals 13
2026 season
Per game, this season.
28.1197 totalScored per gameper game21.9175 total
19.9139 totalConceded per gameper game · lower is better29.8238 total