| # | Rider | Time |
|---|---|---|
| 1 | NORFredrik DversnesUno-X Mobility | 5h 04' 56" |
| 2 | NEDMathieu van der PoelAlpecin–Deceuninck | + 7" |
| 3 | ESPRoger AdriàRed Bull–Bora–Hansgrohe | + 7" |
| 4 | ITAGiulio CicconeLidl–Trek | + 7" |
| 5 | ESPAlex AranburuCofidis | + 7" |
| 6 | GBRTom PidcockQ36.5 Pro Cycling Team | + 7" |
| 7 | FRARomain GrégoireGroupama–FDJ | + 7" |
| 8 | NORTobias Halland JohannessenUno-X Mobility | + 7" |
| 9 | ESPPello BilbaoTeam Bahrain Victorious | + 7" |
| 10 | ITASimone VelascoXDS Astana Team | + 7" |
Times in Sydney time (AEDT). Results: Wikipedia, “2025 Tirreno–Adriatico”, CC BY-SA 4.0. Unofficial, updated after the event.