| # | Rider | Time |
|---|---|---|
| 1 | ESPJuan AyusoUAE Team Emirates XRG | 28h 41' 24" |
| 2 | ITAAntonio TiberiTeam Bahrain Victorious | + 36" |
| 3 | FRAKévin VauquelinArkéa–B&B Hotels | + 1' 52" |
| 4 | FRARomain GrégoireGroupama–FDJ | + 2' 05" |
| 5 | ITADavide PiganzoliTeam Polti VisitMalta | + 2' 11" |
| 6 | MEXIsaac del ToroUAE Team Emirates XRG | + 2' 33" |
| 7 | ITAAlessandro PinarelloVF Group–Bardiani–CSF–Faizanè | + 2' 41" |
| 8 | IRLBen HealyEF Education–EasyPost | + 2' 54" |
| 9 | ITAFlorian Samuel KajaminiXDS Astana Team | + 3' 26" |
| 10 | NORJohannes Staune-MittetDecathlon–AG2R La Mondiale | + 5' 25" |
Times in Sydney time (AEDT). Results: Wikipedia, “2025 Tirreno–Adriatico”, CC BY-SA 4.0. Unofficial, updated after the event.