| # | Rider | Time |
|---|---|---|
| 1 | ESPJuan AyusoUAE Team Emirates XRG | 28h 41' 24" |
| 2 | ITAFilippo GannaINEOS Grenadiers | + 35" |
| 3 | ITAAntonio TiberiTeam Bahrain Victorious | + 36" |
| 4 | CANDerek GeeIsrael–Premier Tech | + 42" |
| 5 | AUSJai HindleyRed Bull–Bora–Hansgrohe | + 53" |
| 6 | GBRTom PidcockQ36.5 Pro Cycling Team | + 56" |
| 7 | ESPMikel LandaSoudal–Quick-Step | + 1' 05" |
| 8 | ESPDavid de la CruzQ36.5 Pro Cycling Team | + 1' 32" |
| 9 | ESPPello BilbaoTeam Bahrain Victorious | + 1' 32" |
| 10 | ITAMattia CattaneoSoudal–Quick-Step | + 1' 38" |
Times in Sydney time (AEDT). Results: Wikipedia, “2025 Tirreno–Adriatico”, CC BY-SA 4.0. Unofficial, updated after the event.